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文献和实验Designing TCR for Cancer Immunotherapy
Reprogramming T-cell populations by T-cell receptor (TCR) gene transfer is a new therapeutic tool for adoptive tumor immunotherapy. Gene transfer of human leukocyte antigen (HLA)-transgenic mice-derived TCR into human T-cells allows
Something Happens; A Brief History of TCR Signal Transduction
scientific years coincide with extraordinary advances in our understanding of the T-cell receptor (TCR) signaling and to have been part of a laboratory that contributed to this field in a major way. First though, a disclaimer: this is a personal and biased
Binding Kinetics of Superantigen with TCR and MHC Class II
There are several key differences between the nature of interactions of a T-cell receptor (TCR) with a conventional MHCpeptide complex and a bacterial superantigen (SAg). Apart from being powerful T-cell mitogens, these SAgs do not require
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