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文献和实验bcl-2 原癌基因(bcl-2 protooncogene)
人的B-淋巴细胞(B-cell lymphomas)中染色体易位激活的原癌基因。bcl即是B-淋巴细胞的英文缩写。该基因编码一种细胞质膜蛋白,能够抑制细胞的程序性死亡。bcl-2原癌基因与秀丽隐杆线虫的ced-9基因同源。
Induction of Programmed Cell Death with an Antisense Bcl-2 Oligonucleotide
(3 ,4 ). Therefore, genetic manipulation of PCD regulatory genes may restore the altered homeostasis in these cells and permit these genetically damaged cells to enter PCD.A known regulator of the PCD pathway is Bcl-2, a protein capable of suppressing cell death
Bcl-2 Family Immunohistochemistry
able to prolong survival by inhibiting programmed cell death (apoptosis) and (b) the discovery of many additional related genes/proteins some of which, like Bcl-2, inhibit apoptosis, whereas others, such as Bax, conversely promote cell death
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