鸡 RAG-2 (Recombination Activat

Analysis of Lymphocyte Development and Function Using the RAG-Deficient Blastocyst Complementation System

The RAG-deficient blastocyst complementation system (RBCS) represents a flexible and rapid method for the genetic analysis of lymphocyte function using a gene-targeting approach. In chimeras derived from manipulated embryonic stem cells injected

In Vivo Gene Delivery into hCD34+ Cells in a Humanized Mouse Model

. In the method presented here, we describe the in vivo gene delivery into hCD34+ cells by intramarrow injection of these new vectors into humanized BALB/c Rag 2 null /IL2rgc null (BALB/c RAGA) mice.

src基因(sarcoma gene)

即鸡肉瘤病毒(SRV)基因组中的基因，可使鸡产生肉瘤。是第一个鉴定的病毒癌基因。1970s,Peter Vogt分离到一种Rous 病毒的突变体，该突变病毒能够感染细胞并进行复制，但是不能致癌。由于该突变体只是丧失了将正常细胞转化为癌细胞的能力，因此推测突变的基因是诱导癌变的基因。后来的分析鉴定发现，该突变体只是缺失了一个基因。由于该基因的缺失，不能诱导肉瘤(sarcoma)的形成，故将此基因命名为src基因。