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文献和实验MuSK: A Kinase Critical for the Formation and Maintenance of the Neuromuscular Junction
Muscle-specific kinase (MuSK) is a RTK that is specifically expressed in skeletal muscle fibers and critical for the formation and maintenance of the neuromuscular junction (NMJ), a peripheral synapse formed between motoneurons
in the post-synaptic membrane. A neuronal protein, agrin, binds to the Musk receptor in the muscle membrane, stimulating clustering of nicotinic receptors and synapse formation. Rapsyn is present at high levels at synapses with nicotinic receptors, bringing
., Granato M. (2009). Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged/MuSK receptor. Neuron 61(5): 721-33. (责任编辑：大汉昆仑王)
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