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文献和实验Inhibition of HIV Infection by Lectin Binding to CD4
target to block infection. One of the first events in the infection of T-cells by the human immunodeficiency virus (HIV) is the binding of the viral envelope glycoprotein gp120 to the differentiation antigen CD4 expressed on the host cell
Differentiation of Mouse Thymocytes in Fetal Thymus Organ Culture
.g., CD4+ T cells vs CD8+ T cells, and TCR-αβ+ T cells vs TCR-γδ+ T cells, 2. clonal selection, e.g., positive selection of useful T-cell clones and negative selection of harmful T-cell clones
Purification of Immature CD4+CD8+ Thymocytes by Panning with Anti-CD8 Antibody
. Immature CD4 − CD8 − thymocytes develop into progeny CD4 + CD8 + thymocytes which maintain low expression of αβTCR. Immature CD4 + CD8 + thymocytes expressing αβTCR of appropriate specificities are selected for further differentiation into mature T cells
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