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文献和实验Molecular Mechanism of ATP-Dependent Solute Transport by Multidrug Resistance-Associated Protein 1
cancer resistance protein and/or multidrug resistance-associated protein 1 (MRP1), confers an acquired MDR due to their capabilities of transporting a broad range of chemically diverse anticancer drugs across the cell membrane barrier. In this review
Multidrug Resistance Proteins and Hepatic Transport of Endo- and Xenobiotics
Transporters that use ATP are called ATP-binding cassette (ABC) transporters. One family of ABC transporters that plays a major role in the ability of the liver to eliminate various drugs is the multidrug resistance proteins (MRPs
cassette transporters, which function as drug efflux pumps such as P-glycoprotein (Pgp) and multidrug resistance-associated protein 1 (MRP1). Because of the hypothesis in the early eighties that blockade of these efflux pumps by modulators would improve
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