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文献和实验Peptide-receptive MHC class I molecules and the TAP (transporter associated with antigen processing) peptide transporter are known to leave the ER and cycle through the cis side of the Golgi apparatus. The amount, and the extent
Assaying Peptide Translocation by the Peptide Transporter TAP
. The peptide transporter TAP translocates peptides over this ER membrane which is critical for successful MHC class I antigen presentation. How peptide translocation by TAP can be assayed and inhibitors of chemical or viral origin can be identified
Typing Alleles of TAP1 and TAP2
TAP1 and TAP2 (for transporter associated with antigen processing) are two ATP-binding bassette (ABC) transporter genes located within the class II region of the human major histocompatibility complex (MHC) (1 ). Their protein products form
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