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文献和实验Human Complement Components C4A and C4B Genetic Diversities: Complex Genotypes and Phenotypes
. 2000. Deficiencies of human complement component C4A and C4B and heterozygosity in length variants of RP‐C4‐CYP21‐TNX (RCCX) modules in Caucasians: The load of RCCX genetic diversity on MHC‐associated disease. J. Exp. Med. 191:2183‐2196
Molecular Analysis of Complement Component C4 Gene Copy Number
isotypes (C4A and C4B) may also lead to susceptibility to autoimmune disease. Therefore, in subjects with autoimmune disease, a low serum C4 level may be due to ongoing disease activity associated with complement activation and consumption
Evaluation of Complement-Dependent Cytotoxicity Using ATP Measurement and C1q/C4b Binding
method to evaluate the binding of C1q on the Fc region and the binding of C4b on cell surface. The luminescence method coupled with complement protein analysis by flow cytometry encompasses all needed methods to evaluate antibody ability to trigger CDC.
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