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- DIMA BIOTECH/缔码生物
- 武汉
- PME48925
- 2025年07月14日
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- 保存条件：
-80°C
- 保质期：
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- 英文名：
Human Dopamine D2 Receptor (DRD2) (NM_000795) Protein
- 库存：
1 week
- 供应商：
缔码生物（武汉）科技有限公司
- 规格：
50 ug
| 产品类别 | ECD Proteins |
|---|---|
| 靶点 | Dopamine D2 Receptor |
| Uniprot ID | P14416 |
| 背景 | This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008] |
| 描述 | Purified recombinant protein of Human dopamine receptor D2 (DRD2), transcript variant 1,Ile214-Gln373, with N-terminal His tag, expressed in E. coli, 50ug |
| 分子量 | 18.3 kDa |
| 纯度 | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| 别名 | D2DR; D2R |
| 标签 | N-His |
| 表达宿主 | E. coli |
| 组分与重悬 | 50mM Tris, 8M Urea, pH8.0. |
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文献和实验Protein Kinase C as a Modulator of 5- HT1A and Dopamine- D2 Receptor Signaling
Since its identification as a family of protein kinases that is activated in the presence of calcium, phosphatidyl serine, and diacylglycerol (DAG), protein kinase C (PKC) has been regarded as one of the early steps in receptor signaling
; Lokhandwala and Chen, 1994 ). Operationally, native membrane-bound dopamine Dl receptors are defined by their ability to stimulate, via Gs or Golf (Herve et al., 1993 ), adenylate cyclase activity which subsequently activates cAMP-dependent protein kinases
Genomic Strategies for the Identification of Dopamine Receptor Genes in Zebrafish
In this chapter, we describe the identification and cloning of D2-like dopamine receptor (DR) genes in zebrafish, a vertebrate model genetic organism. To identify DR genes, we performed searches of the zebrafish genomic sequence database
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