- 询价
- DIMA BIOTECH/缔码生物
- 武汉
- PME46729
- 2025年07月08日
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- 保存条件：
-80°C
- 保质期：
请咨询
- 英文名：
Human Antizyme inhibitor 1 (AZIN1) (NM_015878) Protein
- 库存：
1 week
- 供应商：
缔码生物（武汉）科技有限公司
- 规格：
20 ug
| 产品类别 | ECD Proteins |
|---|---|
| 靶点 | Antizyme inhibitor 1 |
| Uniprot ID | O14977 |
| 背景 | The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014] |
| 描述 | Purified recombinant protein of Human antizyme inhibitor 1 (AZIN1), transcript variant 1, full length, with C-terminal DDK tag, expressed in sf9, 20ug |
| 分子量 | 49.4 kDa |
| 纯度 | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| 别名 | AZI; AZI1; AZIA1; OAZI; OAZIN; ODC1L |
| 标签 | C-DDK |
| 表达宿主 | Sf9 |
| 组分与重悬 | 50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol. |
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文献和实验Nucleic Acid Programmable Protein Arrays: Versatile Tools for Array‐Based Functional Protein Studies
‐88. Ernst, V., Levin, D.H., Foulkes, J.G., and London, I.M. 1982. Effects of skeletal muscle protein phosphatase inhibitor‐2 on protein synthesis and protein
Site‐Specific Protein Labeling with SNAP‐Tags
labeling of cellular proteins with chemical probes is a powerful tool for studying protein function in living cells. A number of small peptide and protein tags have been developed that can be labeled with synthetic probes with high efficiencies
interactions involve the simultaneous binding of two ligands to the same receptor. An allosteric modulator causes a conformational change in the receptor protein that yields a change in the binding or signaling of an orthosteric agent, i.e., an agonist
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