- ￥840 - 2520
- DIMA BIOTECH/缔码生物
- 武汉
- PME30068
- 2025年07月08日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C to -80°C
- 保质期：
12个月
- 英文名：
Human IL-4 (C-Fc) Protein
- 库存：
In Stock
- 供应商：
缔码生物（武汉）科技有限公司
- 规格：
10μg/50μg
| 规格： | 10μg | 产品价格： | ￥840.0 |
|---|---|---|---|
| 规格： | 50μg | 产品价格： | ￥2520.0 |
| 产品类别 | ECD Proteins |
|---|---|
| 背景 | Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 is produced by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of naive CD4 T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergic response. |
| 描述 | Recombinant Human Interleukin-4 is produced by our Mammalian expression system and the target gene encoding His25-Ser153 is expressed with a Fc tag at the C-terminus. |
| 分子结构 | Not available |
| 分子量 | 41.9 KDa |
| 纯度 | Greater than 95% as determined by reducing SDS-PAGE. |
| 储存与运输 | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| 别名 | Interleukin-4;IL-4;B-Cell Stimulatory Factor 1;BSF-1;Binetrakin;Lymphocyte Stimulatory Factor 1;Pitrakinra;IL4 |
| 标签 | C-Fc Tag |
| 有无偶联 | Unconjugated |
| 表达宿主 | HEK293 |
| 形态和组分 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 靶点 | IL-4 |
| Uniprot ID | P05112 |
| 用途 | Research use only |
Figure 1. Greater than 95% as determined by reducing SDS-PAGE.
Figure 2. Loaded Cynomolgus IL-4RA-His on HIS1K Biosensor, can bind Human IL-4-Fc with an affinity constant of <10-3 nM as determined in BLI assay.
Figure 3. Loaded Human IL-4RA-His on HIS1K Biosensor, can bind Human IL-4-Fc with an affinity constant of <10-3 nM as determined in BLI assay.
Figure 4. Immobilized Human IL-4-Fc at 5μg/ml (100 μl/well) can bind Cynomolgus IL-4Ra-His. The ED50 of Recombinant Human IL-4Ra-His is 79.49 ng/ml.
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白细胞介素 IL-4 IL-4主要产生细胞：活化T细胞(Th2)、肥大细胞、嗜酸粒细胞 IL-4氨基酸数目：129 IL-4分子质量(kDa)：18-19 IL-4受体：CDl24；CDl32(γc) IL-4主要生物学活性：促进活化B细胞增殖、分子、Ig产生和类别转换为IgE和IgG1；T细胞生长因子，抑制NK和CTL杀伤活性；促进肥大细胞增殖；增强巨噬细胞功能；协同CSF刺激造血细胞
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