- ￥760 - 2280
- DIMA BIOTECH/缔码生物
- 武汉
- PME30056
- 2025年07月16日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C to -80°C
- 保质期：
12个月
- 英文名：
Human CCL8 (C-6His) Protein
- 库存：
In Stock
- 供应商：
缔码生物（武汉）科技有限公司
- 规格：
10μg/50μg
| 规格： | 10μg | 产品价格： | ￥760.0 |
|---|---|---|---|
| 规格： | 50μg | 产品价格： | ￥2280.0 |
| 产品类别 | ECD Proteins |
|---|---|
| 背景 | Human Chemokine (C-C Motif) Ligand 8 (CCL8) is produced by human MG63 osteosarcoma cells. CCL8 shares 62% and 58% amino acid sequence identity with MCP-1 and MCP-3, respectively. All three MCP proteins are monocyte chemoattractants. CCL8 is chemotactic for and activates many different immune cells, including mast cells, eosinophils and basophils, which are implicated in allergic response, and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors including CCR1, CCR2B and CCR5. |
| 描述 | Recombinant Human C-C Motif Chemokine 8 is produced by our Mammalian expression system and the target gene encoding Gln24-Pro99 is expressed with a 6His tag at the C-terminus. |
| 分子结构 | Not available |
| 分子量 | 9.95 KDa |
| 纯度 | Greater than 95% as determined by reducing SDS-PAGE. |
| 储存与运输 | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| 别名 | C-C Motif Chemokine 8;HC14;Monocyte Chemoattractant Protein 2;Monocyte Chemotactic Protein 2;MCP-2;Small-Inducible Cytokine A8;CCL8;MCP2;SCYA10;SCYA8 |
| 标签 | C-6×His Tag |
| 有无偶联 | Unconjugated |
| 表达宿主 | HEK293 |
| 形态和组分 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 1mM EDTA, pH 7.4. |
| 靶点 | CCL8 |
| Uniprot ID | AAI26243.1 |
| 用途 | Research use only |
Figure 1. Greater than 95% as determined by reducing SDS-PAGE.
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文献和实验Mutational Analysis of the Human Protein C Gene
The single gene for protein C is located at position q13–q14 on chromosome 2 (1 ). Two groups have described human genomic clones of protein C isolated from phage l charon libraries using cDNA for human protein C as hybridization probes
【原创】Protein A Sepharose 之进化篇。。。
洗脱条件比较剧烈，最后收集的蛋白质很有可能变性，或者是复性困难。 这种洗脱条件剧烈的Protein A 柱结合的重组蛋白质A一般具有5个串联结构域：E、D、A、B、C。这种重组蛋白A虽然除去了不重要的非结合域，仅由5个结构域组成，每个域均可以和IgG的Fc段结合，但不同的域结合强度略有差异。因此洗脱条件不均一，而且经常需要较低的pH值。如果减少串联结构域的个数，并且采取同型结构域串联，就可以避免不同结构域与抗体Fc 段亲和性的差异，洗脱条件会温和而均一。为此，我们可以做一个试验，比较一下
第五节 蛋白激酶C 蛋白激酶C（protein kinase C,PKC）是一类Ca 2+ 、磷脂依赖性的蛋白激酶，在跨膜信号传递过程中起着重要作用。PKC通过催化多种蛋白质上Ser/Thr磷酸化，调节多种细胞的代谢、生长、增殖和分化。 表 8-3 哺乳动物组织内的PKC亚类 亚 类 氨基酸残基 分子量（kDa） 激 活 剂 表达组织 A组：经典PKC
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