Fludarabine 氟达拉宾

细胞过继治疗的临床方案

过继转移的T细胞。获得的TIL进一步运用CD3单抗、外源性11_-2以及辐照过的同种异体的PBMC共同培养，进行选择性扩增(细胞数量可达到IOTM)，在细胞过继转移之前测定细胞活性。在给患者输注淋巴细胞之前运用环磷酰胺或Fludarabine治疗去除患者体内的淋巴细胞但保留髓系细胞，或对患者全身辐照进行预处理等。   细胞过继治疗肿瘤的临床方案 从瘤组织中分离细胞，与自体或同系的MHC匹配的肿瘤细胞系进行培养，高水平分泌表达IFN-Y的淋巴细胞即为肿瘤

THP1核酸代谢

of de novo purine biosynthesis; and iii) inhibitors of the purine salvage pathway [11]. It was reported, for example, that the purine nucleoside analogues fludarabine and 2-chlorodeoxyadenosine are very active in chronic lymphocytic leukaemia (CLL