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文献和实验Building a Multiuser Sequence Analysis Facility Using Freeware
and is awkward to use. A good alternative is to build a sequence analysis facility on a local server. BIRCH, the Biological Research Computer Hierarchy, is an example of such a system (http://home.cc.umanitoba.ca/~psgendb and ref. 1). BIRCH is best thought
. In: Essentials of Nuclssseic Acid Analysis: A Robust Approach. Birch L, Keer JT (Eds). Cambridge, UK (2008).
TP53, hChk2, and the Li-Fraumeni Syndrome
. One of the most widely used was defined by Birch et al. (4 ) as Li-Fraumeni-like (LFL) and is a proband with any childhood tumor, or sarcoma, brain tumor, or adrenocortical tumor under 45 years, plus a first- or second-degree relative with a typical LFS tumor at any age
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