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文献和实验Biochemical Analysis of the Native TRAIL Death-Inducing Signaling Complex
The extrinsic apoptosis pathway is activated when certain members of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) are oligomerized by their cognate ligands that are members of the TNF superfamily (TNFSF). The apoptosis
细胞分泌的FasL可以杀伤免疫细胞,使其不能与害自己。这一假说受到如下实验的支持:在体外实验系统,FasL高表达的肿瘤细胞能杀乏Fas阳性的免疫细胞如T细胞。此外,在表达FasL的肿瘤组织可以检测到凋亡的肿瘤启过性淋巴细胞。然而,并非所有的实验结果都与此结果一致。 死亡受体介导的凋亡 (三)TRAIL/Apo2L TNF-α相关凋亡诱导配体(TNF related apoptosis inducing ligand,TRAIL)是从人类基因组数据库中寻找的与TNF(19%同源)和Fas L
Depression‐Related Behavioral Tests
and weaknesses in terms of predictive, face and construct validities. Furthermore, the responses to these tests vary greatly depending on strain of mouse. Depression?related behavioral tests are an extremely useful investigative tool in unearthing causes
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