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- 2025年07月09日
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文献和实验Isolation of Human Tumor-Associated Cell Surface Antigen-Binding scFvs
Several approaches have been used to identify antibody (Ab)-defined human tumor-associated antigens (TAA) that can be used for passive and/or active specific immunotherapy of malignant diseases. For example, hybridoma technology
consists of a cooperation between monocytes and cytophilic antibodies able to bind to the Fc receptors present on the monocyte surface. Thus human IgG1 and IgG3 are the main isotypes effective in ADCI, whereas IgG2, IgG4, and IgM are ineffective
Retroviral Transfer of T-Cell Receptor Genes into Human Peripheral Blood Lymphocytes
We are developing strategies to target tumor-associated antigens (TAA) and viral antigens by genetically modifying patient peripheral blood lymphocytes to produce antitumor or antiviral reactive cytotoxic T-lymphocyte (CTL). To this end
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