PAMAM Dendrimer G3.0 Amidoetha

一种末端为羟基的PAMAM（聚酰胺-胺）树状大分子；在PBS中直径约为30Å，表面有32个官能团；是PA63在脂质膜中的拮抗剂（IC50=44.9nM）；以浓度依赖的方式抑制淀粉样蛋白S20G的聚集；在6µM时抑制淀粉样蛋白S20G诱导的MIN6-K8和NIT-1细胞毒性；包裹地塞米松的PAMAM G3.0氨基乙醇（1mg/ml）局部应用时，可增加地塞米松在分离的兔眼巩膜、结膜和角膜中的水平；在10或100ppm时，减少C.riparius幼虫的尾部生长，并在C.riparius幼虫匀浆中诱导DNA损伤。A hydroxyl-terminated PAMAM dendrimer; ~30 Å in diameter in PBS and has 32 surface groups; an antagonist for PA63 in lipid membranes (IC50 = 44.9 nM); inhibits amylinS20G aggregation in a concentration-dependent manner; inhibits amylinS20G-induced toxicity in MIN6-K8 and NIT-1 cells at 6 µM; topical application of PAMAM G3.0 amidoethanol (1 mg/ml) encapsulating dexamethasone increases the levels of dexamethasone in the sclera, conjunctiva, and cornea in isolated rabbit eyes; reduces tail growth in C. riparius larvae and induces DNA damage in C. riparius larval homogenates at 10 or 100 ppm.分子式[NH2(CH2)2NH2]:(G=3);dendri PAMAM(NHCH2CH2OH)32分子量6940.4