Melittin (C-Term Cysteine labe

一种蜂毒肽衍生物；在胞内体和胞外pH下诱导分离的人类红细胞溶血（pH5.5和7.4时EC50分别为5和6µM）；已用于合成膜溶解聚合物，该聚合物已用于生成用于体外和体内质粒递送的多聚复合物。A melittin derivative; induces hemolysis of isolated human red blood cells at endosomal and extracellular pHs (EC50s = 5 and 6 µM at pH 5.5 and 7.4, respectively); has been used in the synthesis of membrane-lytic polymers that have been used in the generation of polyplexes for plasmid delivery in vitro and in vivo.分子式C134H234N40O32S • XCF3COOH分子量2949.6[H]NCC(N[C@]([C@H](CC)C)([H])C(NCC(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@]([C@@H](C)O)([H])C(N[C@]([C@@H](C)O)([H])C(NCC(N[C@@H](CC(C)C)C(N1CCC[C@H]1C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CO)C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N)=O)CS)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CNC3=C2C=CC=C3)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O.OC(C(F)(F)F)=O