KDM4D-IN-1

JMJD2D抑制剂(IC50=0.41µM)；对JMJD2D具有选择性，优于JMJD1B、JMJD2B和JARID1A（所有IC50s=>10µM）；0.5µM时可降低Caki-1透明细胞肾癌细胞和786-O腺癌细胞的集落形成、迁移和侵袭；在786-O小鼠异种移植模型中减少肿瘤生长和血管发育。An inhibitor of JMJD2D (IC50 = 0.41 µM); selective for JMJD2D over JMJD1B, JMJD2B, and JARID1A (IC50s = >10 µM for all); decreases the colony formation, migration, and invasion of Caki-1 clear cell renal carcinoma cells and 786-O adenocarcinoma cells at 0.5 µM; reduces tumor growth and vessel development in a 786-O mouse xenograft model.分子式C11H7N5O分子量225.2N#CC(C(C)=NN1C2=NC=CC=C23)=C1NC3=O