Hispidol

一种具有多种生物活性的橙酮；是酪氨酸酶、MAO-A和MAO-B的抑制剂（IC50s=38.4、0.26和2.45µM）；在50µM浓度下，可增加无细胞测定中的过氧化氢酶和SOD活性，并降低C.elegans中的细胞内ROS，延长其寿命；在2、5和15mg/kg浓度下，可减少小鼠在强迫游泳和悬尾测试中的静止时间。An aurone with diverse biological activities; is an inhibitor of tyrosinase, MAO-A, and MAO-B (IC50s = 38.4, 0.26, and 2.45 µM); increases catalase and SOD activity in cell-free assays, as well as decreases intracellular ROS in, and increases the lifespan of, C. elegans at 50 µM; decreases immobility time in forced swim and tail suspension tests in mice at 2, 5, and 15 mg/kg.分子式C15H10O4分子量254.2O=C1C2=CC=C(O)C=C2O/C1=C\C3=CC=C(C=C3)O