STING Agonist 23

STING激动剂；在20µM浓度下可增加野生型HT-1080细胞中的TBK1磷酸化，但不增加STING缺陷型细胞中的TBK1磷酸化；诱导THP-1细胞和小鼠BMDM中的STING二聚化；体外抑制HSV、RRV和SARS-CoV-2的复制（EC50s分别为6.15、6.8和10.71µM）；增加小鼠血清中的IFN-β和TNF-α水平。A STING agonist; increases TBK1 phosphorylation in wild-type, but not STING-deficient, HT-1080 cells at 20 µM; induces dimerization of STING in THP-1 cells and mouse BMDMs; inhibits the replication of HSV, RRV, and SARS-CoV-2 in vitro (EC50s = 6.15, 6.8, and 10.71 µM, respectively); increases serum levels of IFN-β and TNF-α in mice.分子式C15H16N4O8分子量380.3O=C(NCCCCCNC(C1=CC=C([N+]([O-])=O)O1)=O)C2=CC=C([N+]([O-])=O)O2