hVEGF-IN-1

VEGFA翻译抑制剂；与编码VEGF-A(Kd=4.64µM)的mRNA结合，并在1.5µM时降低其翻译；在3µM时降低MCF-7细胞的迁移；在MCF-7小鼠异种移植模型中，以每天7.5mg/kg的剂量降低肿瘤生长和重量，而不会降低体重。An inhibitor of VEGFA translation; binds to the mRNA encoding for VEGF-A (Kd = 4.64 µM) and decreases its translation at 1.5 µM; reduces migration of MCF-7 cells at 3 µM; decreases tumor growth and weight without reducing body weight in an MCF-7 mouse xenograft model at 7.5 mg/kg per day.分子式C34H43N7O2分子量581.8O=C(CCN1CCN(CC1)C)NC2=C(C3=NC4=C(C(NC5=CC=C(C=C5)OCCN(CC)CC)=N3)C=CC=C4)C=CC=C2