N6-Benzyladenosine-5'-O-diphos

一种ADP衍生物和N6-苄基腺嘌呤的活性代谢物；抑制mortalin、Hsp70和Hsc70的ATPase活性（对于人类酶，表观Kis分别为86.51、294.5和1,612µM）；抑制CEM、HL-60、K562、RPMI-8226和MCF-7细胞的增殖（IC50s分别为2、1.3、4、4.5和8µM）；已用于合成放射性标记和未标记形式的N6-苄基-ATPγS。An ADP derivative and active metabolite of N6-benzyladenine; inhibits the ATPase activities of mortalin, Hsp70, and Hsc70 (apparent Kis = 86.51, 294.5, and 1,612 µM, respectively, for the human enzymes); inhibits the proliferation of CEM, HL-60, K562, RPMI-8226, and MCF-7 cells (IC50s = 2, 1.3, 4, 4.5, and 8 µM, respectively); has been used in the synthesis of radiolabeled and unlabeled forms of N6-benzyl-ATPγS.分子式C17H18N5O10P2 • 3Na分子量583.3O[C@@H]1[C@@H](COP(OP([O-])([O-])=O)([O-])=O)O[C@@H](N2C3=NC=NC(NCC4=CC=CC=C4)=C3N=C2)[C@@H]1O.[Na+].[Na+].[Na+]