[Leu144, Arg147]-PLP (139-151)

PLP肽的突变片段；在CFA中乳化50µg进行免疫时，可提高小鼠脾脏中的IL-4水平；体外抑制Th1细胞活化，但在体内不抑制，在体内诱导调节性T细胞的产生；延迟小鼠中PLP(178-191)-、MOG(92-106)-或MBP诱发的EAE的发生。A mutant fragment of PLP peptide; increases spleen levels of IL-4 in mice when administered at 50 µg emulsified in CFA as an immunization; inhibits Th1 cell activation in vitro but not in vivo, where it induces the generation of regulatory T cells; delays the onset of PLP (178-191)-, MOG (92-106)-, or MBP-induced EAE in mice.分子式C67H110N20O17 • XCF3COOH分子量1467.7OC([C@H](CC1=CC=CC=C1)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@H]2N(CCC2)C([C@H](CCCNC(N)=N)NC(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC([C@H](CO)NC([C@@H](N)CC3=CN=CN3)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O