Hinokiflavone

一种具有多种生物活性的双黄酮类化合物；体外抑制Aβ40的聚集（IC50=9.5μM）；10µM时促进NB4细胞中编码Mcl-1和eIF4α的基因的前mRNA剪接并抑制编码Hsp40和RIOK3的基因的前mRNA剪接；10µM时增加HEK293细胞中的蛋白质SUMO化；降低甲型流感亚型H1N1和H1N3、乙型流感、副流感病毒3型和RSV的细胞病变作用（IC50分别为1.4、1.3、1.2、1和2.5µg/ml）；10-40µM时抑制KYSE-150细胞的迁移和侵袭并诱导细胞凋亡；以25或50mg/kg的剂量减少KYSE-150小鼠异种移植模型中的肿瘤体积。A biflavonoid with diverse biological activities; inhibits the aggregation of Aβ40 in vitro (IC50 = 9.5 μM); promotes pre-mRNA splicing of the genes encoding Mcl-1 and eIF4α and inhibits pre-mRNA splicing of the genes encoding Hsp40 and RIOK3 in NB4 cells at 10 µM; increases protein SUMOylation in HEK293 cells at 10 µM; reduces the cytopathic effect of the influenza A subtypes H1N1 and H1N3, influenza B, parainfluenza type 3, and RSV (IC50s = 1.4, 1.3, 1.2, 1, and 2.5 µg/ml, respectively); inhibits the migration and invasion of, and induces apoptosis in, KYSE-150 cells from 10-40 µM; reduces tumor volume in a KYSE-150 mouse xenograft model at 25 or 50 mg/kg.分子式C30H18O10分子量538.5O=C1C=C(C2=CC=C(C=C2)OC3=C(C=C4OC(C5=CC=C(O)C=C5)=CC(C4=C3O)=O)O)OC6=CC(O)=CC(O)=C16