2-Acetamido-2,4-dideoxy-4-fluo

Treating Respiratory Viral Diseases with Chemically Modified, Second Generation Intranasal siRNAs

) that were chemically modified and screened for improved stability, activity and pharmacokinetics. 2′-O -methyl (2′-O -Me) and 2′-deoxy-2′-fluoro (2′-F) substitutions in the ribose ring were incorporated in different positions of the sense and antisense strands

Crystallographic Analyses of Chemically Synthesized Modified Hammerhead RNA Sequences as a General Approach Toward Understanding Ribozyme Structure an

, the crystal structure of an all-RNA hammerhead ribozyme containing a modified 2′-O -methylcytosine at the active site to prevent cleavage has recently been solved (2 ,3 ). Incorporation of the 2′-methoxyl moiety specifically at the cleavage site

Determination of Sulfur Amino Acids, Glutathione, and Related Aminothiols in Biological Samples by Gas Chromatography with Flame Photometric Detection

, the ultraviolet (UV) (9 –12 ), and the postcolumn UV derivatization with 4,4′-dithiopyridine (13 ) and 5,5-dithiobis (2-nitrobenzoic acid) (14 ), the precolumn fluorescence derivatization with 4-(aminosulfonyl)- or ammonium-7-fluoro-2,1,3-benzoxadiazole