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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Human
- 亚型:
IgG1, lambda2
- 形态:
Liquid
- 保存条件:
/
- 克隆性:
Monoclonal
- 标记物:
Unconjugated
- 适应物种:
Human
- 保质期:
1 year
- 抗原来源:
Human
- 目录编号:
HT224016
- 级别:
科研级别
- 库存:
999
- 供应商:
abinScience
- 宿主:
Human
- 应用范围:
Research Grade Biosimilar
- 浓度:
1mg/mL
- 靶点:
MUSK
- 抗体英文名:
Research Grade adimanebart
- 抗体名:
Research Grade adimanebart
- 规格:
100ug

| Product name | Research Grade adimanebart |
|---|---|
| Catalog No. | HT224016 |
| Host species | Human |
| Conjugation | / |
| Species reactivity | Human |
| Immunogen | / |
| Form | Liquid |
| Storage buffer | / |
| Purity | >95% as determined by SDS-PAGE. |
| Clonality | Monoclonal |
| Applications | Research Grade Biosimilar |
| Target | MUSK |
| Purification | / |
| Endotoxin level | Please contact with the lab for this information. |
| Accession | O15146 |
| Background | Muscle, skeletal receptor tyrosine-protein kinase (O15146 plays a crucial role in receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (nmj, the synapse between the motor neuron and the skeletal muscle 25537362. recruitment of agrin by lrp4 to the musk signaling complex induces phosphorylation and activation of musk, the kinase of the complex. the activation of musk in myotubes regulates the formation of nmjs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (achr in the postsynaptic membrane. may regulate achr phosphorylation and clustering through activation of abl1 and src family kinases which in turn regulate musk. dvl1 and pak1 that form a ternary complex with musk are also important for musk-dependent regulation of achr clustering. may positively regulate rho family gtpases through fnta. mediates the phosphorylation of fnta which promotes prenylation, recruitment to membranes and activation of rac1 a regulator of the actin cytoskeleton and of gene expression. other effectors of the musk signaling include dnaja3 which functions downstream of musk. may also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (by similarity. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Alternative Names | CAS: 3011838-77-7 |
| Clone ID | / |
| Species | Human |
| Shipping | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note | For research use only. Not for use in clinical or therapeutic applications. |
Abinscience, founded in 2023 and located in the innovation technology center in Strasbourg, France, is the core research reagent brand of ProteoGenix. Focusing on the development and production of life science research reagents, Abinscience takes "Empowering Bioscience Discovery" as its vision, and is committed to providing high-quality and innovative biological reagent products and technical solutions for global researchers.
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文献和实验Wang Y, Mandelkow E. Tau in physiology and pathology[J]. Nature reviews neuroscience, 2016, 17(1): 22-35.
【操作步骤】6.2 分文章作者,亲手教你如何轻松搞定生信文章
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