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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
Short term 4℃; Long term -20℃.
- 保质期:
见COA
- 英文名:
Recombinant Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer, His-tag
- 库存:
大量
- 供应商:
北京辰辉创聚生物技术有限公司
- 规格:
100ug;1mg;Bulk

| 产品信息
品名:NebuSelect™ Recombinant Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer, His-tag
货号:NBL-242414
品牌:Nebulabio
规格:100ug;1mg;Bulk
| 产品描述
NebuSelect™ Recombinant Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer, His-tag(Cat#NBL-242414) is expressed in HEK293 with His tag at the C-Terminus.It contains Phe31-Val988(ITGAV) acidic tail&Gly22-Asn706(ITGB6) basic tail.
| 产品属性
表达系统:HEK293
标签:His-tag
靶点名称:Integrin alpha V beta 6 (ITGAV&ITGB6)
物种:Mouse
分子量:The protein has a predicted MW of 111.6 kDa (ITGAV)&79.2 kDa (ITGB6). Due to glycosylation, the protein migrates to 90-140 kDa based on Bis-Tris PAGE result.
氨基酸序列:
Accession: P43406(ITGAV)&Q9Z0T9(ITGB6)
纯度:>95%
内毒素:<1EU/ug(LAL Method)
储存运输条件: Short term 4℃; Long term -20℃.
| 靶点信息
ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
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文献和实验由胞膜外区、胞浆区、穿膜区三部分组成。胞浆区一般较短,可能和细胞骨架相联。空膜区富含疏水氨基酸。β亚单位的胞膜外区含有4个富含半胱氨酸的重复序列,靠近外侧N端的40~50kDa的氨基酸残基通过链内二硫键紧密折叠在一起;α亚单位的胞膜外部分有7个同源重复序列,靠近外侧N端的3个或4个重复序列中含有Asp-X-Asp-X-Asp-Gly-X-X-Asp或类似结构,与integrin分子结合二价阳离子(Mg2+)有关,并与β亚单位共同构成粘合素分子的配体
v468. chapter 4 WNT 细胞通路 检测细胞GSK3活性与表达水平
-catenin. FEBS Lett. 458, 247–251. 10. Ding, V. W., Chen, R. H., and McCormick, F. (2000) Differential regulation of glycogensynthase kinase 3beta by insulin and Wnt signaling. J. Biol. Chem. 275, 32475– 32481. 11. Liu, X., Rubin, J. S., and Kimmel, A. R
Generation of Spatio‐Temporally Controlled Targeted Somatic Mutations in the Mouse
Indra, A.K., Li, M., Brocard, J., Warot, X., Bornert, J.M., Gerard, C., Messaddeq, N., Chambon, P., and Metzger, D. 2000. Targeted somatic mutagenesis in mouse epidermis. Horm. Res. 54:296‐300.
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