Anti-Disialoganglioside GD2, c

Disialoganglioside GD2 is a glycosphingolipid found on the surface of certain cancer cells, particularly in neuroblastoma, melanoma, and small cell lung cancer. GD2 is a type of ganglioside, a class of lipids that contain sialic acid residues, and it is involved in various cellular processes such as cell signaling, adhesion, and immune evasion. In normal tissues, GD2 expression is typically limited to the nervous system during development, but its expression is significantly upregulated in several types of tumors. Due to its restricted expression in normal adult tissues and high presence in various cancers, GD2 has become a target for cancer immunotherapy. Monoclonal antibodies targeting GD2, such as dinutuximab, are being used in clinical treatments, especially in neuroblastoma, making GD2 a significant biomarker and therapeutic target in oncology.