Anti-MDR-1/ABCB1 Recombinant R

MDR-1 (Multidrug Resistance Protein 1), also known as P-glycoprotein (P-gp), is a membrane-bound transport protein that plays a critical role in the efflux of a variety of substrates, including drugs and toxins, out of cells. It is part of the ATP-binding cassette (ABC) transporter family and is primarily expressed in tissues such as the liver, kidneys, intestines, and the blood-brain barrier. MDR-1 is important for protecting cells from harmful substances but can also contribute to drug resistance in cancer by actively pumping chemotherapeutic agents out of tumor cells, reducing their efficacy. Understanding MDR-1's function is crucial for developing strategies to overcome multidrug resistance in cancer therapy.