Anti-integrin β3 Recombinant R

Integrin beta-3 (ITGB3) is a crucial subunit of the integrin family, a group of transmembrane receptors that mediate cell adhesion to the extracellular matrix and to other cells. Integrin beta-3 pairs with different alpha subunits, such as alpha-v (αv) and alpha-IIb (αIIb), to form integrins like αvβ3 and αIIbβ3. These integrins are involved in a wide range of cellular processes, including cell migration, signal transduction, and platelet aggregation. αvβ3 is particularly important in angiogenesis, the formation of new blood vessels, while αIIbβ3 is essential for platelet function and blood clotting. Integrin beta-3’s dysregulation has been implicated in various diseases, including cancer, where it contributes to tumor progression and metastasis, as well as thrombotic disorders.