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- CAS号：
31005-02-4
7-Ethoxycoumarin
31005-02-4
C₁₁H₁₀O₃
190.2
Off-White to Pale Brown Solid
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
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文献和实验7-Ethoxycoumarin
31005-02-4
C₁₁H₁₀O₃
190.2
Off-White to Pale Brown Solid
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
Use of 7-Ethoxycoumarin to Monitor Multiple Enzymes in the Human CYP1, CYP2, and CYP3 Families
7-Ethoxycoumarin is metabolized by many cytochrome P450 enzymes active in foreign compound metabolism and has been used as a prototypic substrate to monitor P450 (P450) activity in both hepatic and extrahepatic tissues. A spectrofluorometric
Use of 7-Ethoxycoumarinto Monitor Multiple Enzymesin the Human CYP1, CYP2, and CYP3 Families
of a general P4.50 substrate is 7-ethoxycoumarin. Enzyme kinetic analysis with human liver microsomes indicates that 7-ethoxycoumarin is metabolized by at least two P450 enzymes or by two groups of P450 enzymes that are kinetically distmguishable
have been ldentlfied for cDNA-expressed CYP2B6, including I-l-ethoxycoumarin (3 , 7 , 8 ), benzo[a]pyrene (9 ), phenanthrene (10 ), and methoxychlor (11 ). However, little is known regardmg the role of this P450 in drug metabolism, although cDNA-expressed CYP
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