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文献和实验The v-erbA oncogene is the most clear-cut case of an oncogene that acts by blocking a differentiation sequence (for a review, see ref. 1 ). It has been discovered as one of the two oncogenes carried by the avian erythroblastosis virus (AEV
The proto-oncogene c-myb is a cellular homolog of a viral oncogene v-myb found in two independently derived avian acute leukemia viruses: avian myeloblastosis vn-us (AMV) and E26 leukemia virus (1 ). The myb gene is highly conserved
, which was originally identified as a spliced and polyadenylated but noncoding RNA (ncRNA), ~1700 nucleotides long, accumulating in certain chicken B cell lymphomas. In lymphomas that developed upon infection with avian leukosis virus (ALV), synthesis of BIC RNA
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