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- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
Osimertinib
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
1421373-65-0
纯度：>98% by HPLC；NMR (Conforms)
分子式：C28H33N7O2
分子量：499.62
溶剂：DMSO (40 mg/ml)
性状：Pale-yellow solid
存储：-20°C
Activity (short version)：Mutant EGFR kinase inhibitor
Function / Pharmacology：Osimertinib is a potent, selective, irreversible inhibitor of mutant EFGR tyrosine kinase.1 Osimertinib inhibits phosphorylation of EGFR in T790M-mutant cell lines (IC50 <15 nM) but was less potent at inhibition of EGFR phosphorylation in wild-type cells (IC50s in the range of 480 to 1,865 nM). It produces sustained tumor regression in EGFR-mutant tumor xenograft and transgenic rodent models.2 Tumor cells develop resistance to osimertinib but combination treatment with an IL-6 antibody reverses resistance to a certain extent.3 In clinical use for treatment of non-small cell lung cancer.4
分子式：C28H33N7O2
分子量：499.62
溶剂：DMSO (40 mg/ml)
性状：Pale-yellow solid
存储：-20°C
Activity (short version)：Mutant EGFR kinase inhibitor
Function / Pharmacology：Osimertinib is a potent, selective, irreversible inhibitor of mutant EFGR tyrosine kinase.1 Osimertinib inhibits phosphorylation of EGFR in T790M-mutant cell lines (IC50 <15 nM) but was less potent at inhibition of EGFR phosphorylation in wild-type cells (IC50s in the range of 480 to 1,865 nM). It produces sustained tumor regression in EGFR-mutant tumor xenograft and transgenic rodent models.2 Tumor cells develop resistance to osimertinib but combination treatment with an IL-6 antibody reverses resistance to a certain extent.3 In clinical use for treatment of non-small cell lung cancer.4
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文献和实验该产品被引用文献
1421373-65-0
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Osimertinib
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