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- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
Apilimod
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
541550-19-0
纯度：99% by HPLC；NMR (Conforms)
分子式：C23H26N6O2
分子量：418.5
溶剂：DMSO (>25 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：IL/12 and 23/PIKfyve inhibitor
Function / Pharmacology：Potent (IC50 = 10 nM IFN-g/LPS-stimulated human PMBC’s; IC50 = 1 nM in IFN-g/SAC-stimulated human PMBC’s) IL-12/IL-23 inhibitor downregulating both at the transcriptional level. Suppresses Th1 but not Th2 immune response.1 Inhibition was also observed in human monocytes, monocyte-derived dendritic cells, and THP-1 cells. Apilimod’s mechanism of action is mediation of TLR signaling via inhibition of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve; IC50 = 14 nM).2 It displayed selective cytotoxic activity in B-cell non-Hodgkin lymphoma compared with normal cells.3 Apilimod prevented infection of VSV-ZEBOV and VSV-SARS-CoV-2 (IC50 = 50 nM) as well as SARS-CoV-2 strain 2019-nCoVB/USA-1WA/2020.4
分子式：C23H26N6O2
分子量：418.5
溶剂：DMSO (>25 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：IL/12 and 23/PIKfyve inhibitor
Function / Pharmacology：Potent (IC50 = 10 nM IFN-g/LPS-stimulated human PMBC’s; IC50 = 1 nM in IFN-g/SAC-stimulated human PMBC’s) IL-12/IL-23 inhibitor downregulating both at the transcriptional level. Suppresses Th1 but not Th2 immune response.1 Inhibition was also observed in human monocytes, monocyte-derived dendritic cells, and THP-1 cells. Apilimod’s mechanism of action is mediation of TLR signaling via inhibition of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve; IC50 = 14 nM).2 It displayed selective cytotoxic activity in B-cell non-Hodgkin lymphoma compared with normal cells.3 Apilimod prevented infection of VSV-ZEBOV and VSV-SARS-CoV-2 (IC50 = 50 nM) as well as SARS-CoV-2 strain 2019-nCoVB/USA-1WA/2020.4
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541550-19-0
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