- 询价
- WYTSCI
- 进口
- WT-AY-B11349
- 2025年07月08日
1 年钻石会员
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
Lomitapide
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
182431-12-5
纯度：>98% by HPLC；NMR (Conforms)
分子式：C39H37F6N3O2
分子量：693.73
溶剂：DMSO (50 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：Microsomal triglyceride transfer protein inhibitor
Function / Pharmacology：Lomitapide is a potent (IC50 = 8 nM) inhibitor of microsomal triglyceride transfer protein (MTP or MTTP) and is clinically useful in treating familial hypercholesterolemia.1,2 It has displayed anticancer activity acting through various pathways including autophagy-dependent cancer cell death via direct inhibition of the kinase activity of mTORC13, activation of AMPK/Beclin1-mediated autophagy4, Notch inhibition via targeting TACE and γ-secretase5, blocking ZDHHC5-dependent palmitoylation on SSTR56, PFKFB3 inhibition7, and PARP14/DRP1-mediated mitophagy8.
分子式：C39H37F6N3O2
分子量：693.73
溶剂：DMSO (50 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：Microsomal triglyceride transfer protein inhibitor
Function / Pharmacology：Lomitapide is a potent (IC50 = 8 nM) inhibitor of microsomal triglyceride transfer protein (MTP or MTTP) and is clinically useful in treating familial hypercholesterolemia.1,2 It has displayed anticancer activity acting through various pathways including autophagy-dependent cancer cell death via direct inhibition of the kinase activity of mTORC13, activation of AMPK/Beclin1-mediated autophagy4, Notch inhibition via targeting TACE and γ-secretase5, blocking ZDHHC5-dependent palmitoylation on SSTR56, PFKFB3 inhibition7, and PARP14/DRP1-mediated mitophagy8.
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验该产品被引用文献
182431-12-5
技术资料暂无技术资料 索取技术资料
文献支持
Lomitapide
询价
