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- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
Enasidenib
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
1446502-11-9
纯度：98%,；NMR (Conforms)
分子式：C19H17F6N7O
分子量：473.38
溶剂：DMSO (25 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：IDH2 inhibitor
Function / Pharmacology：Enasidenib is a potent (IC50’s = 100 nM IDH2R140Q homodimer, 30 nM IDH2R140Q/WT heterodimer and 10 nM IDH2R172K/WT heterodimer) and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2).1 It suppressed the production of the oncometabolite (R)-2-Hydroxyglutarate (a competitive inhibitor of αKG-dependent dioxygenases which leads to epigenetic dysregulation) and induced cellular differentiation in primary human IDH2 mutation-positive acute myeloid leukemia cells.1,2 Recently approved for clinical use by the FDA.
分子式：C19H17F6N7O
分子量：473.38
溶剂：DMSO (25 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：IDH2 inhibitor
Function / Pharmacology：Enasidenib is a potent (IC50’s = 100 nM IDH2R140Q homodimer, 30 nM IDH2R140Q/WT heterodimer and 10 nM IDH2R172K/WT heterodimer) and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2).1 It suppressed the production of the oncometabolite (R)-2-Hydroxyglutarate (a competitive inhibitor of αKG-dependent dioxygenases which leads to epigenetic dysregulation) and induced cellular differentiation in primary human IDH2 mutation-positive acute myeloid leukemia cells.1,2 Recently approved for clinical use by the FDA.
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1446502-11-9
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Enasidenib
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