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- 文献和实验
- 技术资料
- 保存条件:
-20°C
- 保质期:
咨询
- 英文名:
AZD7648
- 库存:
1000+
- 供应商:
上海维亦特生物
- CAS号:
2230820-11-6
分子式:C18H20N8O2
分子量:380.41
溶剂:DMSO (5 mg/ml with warming)
性状:White solid
存储:-20°C
Activity (short version):DNA-PK inhibitor/CRISPR enhancer
Function / Pharmacology:AZD7648 is a very potent and selective (against 397 kinases) DNA-PK inhibitor (pIC50 = 9.2; cellular pIC50 = 7.0).1 It is a sensitizer of radiation- and doxorubicin-induced DNA damage and sustained tumor regression in xenograft and patient-derived xenograft models.2 AZD7648 significantly enhances precise CRISPR/Cas9 gene editing alone3,4,5 or in combined treatment with a DNA polymerase theta inhibitor (2iHDR cocktail)5.
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为什么你的 qPCR 重复性差?灵敏度低?扩增易受抑制?那是你还不知道数字 PCR
for copy number analysis of the CCL4L genes." Infection, Genetics and Evolution 25 (2014): 28 - 35.4.Oxnard, Geoffrey R., et al. "Association between plasma genotyping and outcomes of treatment with osimertinib (AZD9291) in advanced non–small-cell lung
Biochemistry 39, 4383-4390. 12. Hori, Y. , Suzuki, K. , Okuno, Y. , Nagaoka, M. , Futaki, S , and Sugiura, Y. (2000) Artificial zinc finger peptidecontaining a novel His4 domain. J.Arru Ckerru Soc. 122, 7648-7653. 13. Nagaoka, M
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