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- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
Serodolin
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
1814929-81-1
纯度：>98% by HPLC；NMR (Conforms)
分子式：C22H27FN4O
分子量：382.47
溶剂：DMSO (50 mg/ml)
性状：Off-white solid
存储：-20°C
Activity (short version)：ß-Arrestin-biased 5-HT7 antagonist
Function / Pharmacology：Serodolin is a potent dual antagonist of the serotonin receptors 5-HT7 (Ki = 6.2 nM; IC50 = 5.7 nM cAMP response) and 5-HT2A (Ki = 19 nM; IC50 = 110 nM IP1 response) with significant selectivity over 5-HT1A and 5-HT6.1 Serodolin has recently been found to act as a ß-arrestin-biased inverse agonist on Gs signaling while inducing ERK activation requiring c-SRS activation, a unique pharmacological profile among 5-HT7 ligands.2 It decreased hyperalgesia and pain sensation in response to inflammatory, thermal, and mechanical stimulation in a mouse model demonstrating the therapeutic potential of a ß-arrestin-biased ligand for pain relief. Blood-brain barrier permeable.
分子式：C22H27FN4O
分子量：382.47
溶剂：DMSO (50 mg/ml)
性状：Off-white solid
存储：-20°C
Activity (short version)：ß-Arrestin-biased 5-HT7 antagonist
Function / Pharmacology：Serodolin is a potent dual antagonist of the serotonin receptors 5-HT7 (Ki = 6.2 nM; IC50 = 5.7 nM cAMP response) and 5-HT2A (Ki = 19 nM; IC50 = 110 nM IP1 response) with significant selectivity over 5-HT1A and 5-HT6.1 Serodolin has recently been found to act as a ß-arrestin-biased inverse agonist on Gs signaling while inducing ERK activation requiring c-SRS activation, a unique pharmacological profile among 5-HT7 ligands.2 It decreased hyperalgesia and pain sensation in response to inflammatory, thermal, and mechanical stimulation in a mouse model demonstrating the therapeutic potential of a ß-arrestin-biased ligand for pain relief. Blood-brain barrier permeable.
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文献和实验该产品被引用文献
1814929-81-1
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