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- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
BZ1
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
2766623-38-3
纯度：98% by HPLC；NMR (Conforms)
分子式：C13H15ClN4O
分子量：278.74
溶剂：DMSO (50 mg/ml); Ethanol (50 mg/ml)
性状：Yellow solid
存储：-20°C
Activity (short version)：BPTF inhibitor
Function / Pharmacology：Potent (Kd = 6.3 nM; IC50 = 67 nM BPTF Alphascreen) inhibitor of the bromodomain PHD finger transcription factor (BPTF). It displays >350-fold selectivity over BET bromodomains. BZ1 sensitized 4T1 mouse breast cancer cells to doxorubicin treatment. BPTF inhibition represents a potential strategy for the inhibition of nucleosome remodeling factor (NURF) and exploration of its function.
分子式：C13H15ClN4O
分子量：278.74
溶剂：DMSO (50 mg/ml); Ethanol (50 mg/ml)
性状：Yellow solid
存储：-20°C
Activity (short version)：BPTF inhibitor
Function / Pharmacology：Potent (Kd = 6.3 nM; IC50 = 67 nM BPTF Alphascreen) inhibitor of the bromodomain PHD finger transcription factor (BPTF). It displays >350-fold selectivity over BET bromodomains. BZ1 sensitized 4T1 mouse breast cancer cells to doxorubicin treatment. BPTF inhibition represents a potential strategy for the inhibition of nucleosome remodeling factor (NURF) and exploration of its function.
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2766623-38-3
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