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- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
Selinexor
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
1393477-72-9
纯度：98% by TLC；NMR (Conforms)
分子式：C17H11F6N7O
分子量：443.31
溶剂：DMSO (>25 mg/ml) Ethanol (>25 mg/ml)
性状：Off-white solid
存储：-20°C
Activity (short version)：CRM1/XPO1 nuclear export receptor inhibitor
Function / Pharmacology：Selinexor is a potent inhibitor of the nuclear export receptor, chromosome region maintenance 1 (CRM1; Exportin-1 (XPO1)). It exhibited potent growth suppression in various T-cell acute lymphoblastic leukemia (T-ALL) cells (IC50’s = 34-203 nM)1 and pancreatic cancer cells (IC50 ~ 150 nM)2. Selinexor is being investigated as a possible chemotherapeutic in treating multiple types of cancer.3-8 Currently in clinical trials.
分子式：C17H11F6N7O
分子量：443.31
溶剂：DMSO (>25 mg/ml) Ethanol (>25 mg/ml)
性状：Off-white solid
存储：-20°C
Activity (short version)：CRM1/XPO1 nuclear export receptor inhibitor
Function / Pharmacology：Selinexor is a potent inhibitor of the nuclear export receptor, chromosome region maintenance 1 (CRM1; Exportin-1 (XPO1)). It exhibited potent growth suppression in various T-cell acute lymphoblastic leukemia (T-ALL) cells (IC50’s = 34-203 nM)1 and pancreatic cancer cells (IC50 ~ 150 nM)2. Selinexor is being investigated as a possible chemotherapeutic in treating multiple types of cancer.3-8 Currently in clinical trials.
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文献和实验该产品被引用文献
1393477-72-9
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Selinexor
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