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- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
RU.521
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
2262452-06-0
纯度：98% by TLC；NMR (Conforms)
分子式：C19H12Cl2N4O3
分子量：415.23
溶剂：DMSO (>25 mg/ml)
性状：Off-white to pale pink solid
存储：-20°C
Activity (short version)：cGAS inhibitor
Function / Pharmacology：Inhibitor of cyclic GMP-AMP synthase (cGAS), an important innate immune system sensor of foreign cytoplasmic double-stranded DNA.1,2 IC50 = 0.70 µM in dsDNA-stimulated RAW macrophages1 and ~0.80 µM in wild type human THP-1 cells2. It is selective for cGAS with no targeting of IFNB1 protein, interferon receptors, or downstream signaling components of the JAK/STAT pathway. RU.521 was able to significantly increase cardiac output in a mouse model of sepsis.3 Active in both mouse and human cell lines.
分子式：C19H12Cl2N4O3
分子量：415.23
溶剂：DMSO (>25 mg/ml)
性状：Off-white to pale pink solid
存储：-20°C
Activity (short version)：cGAS inhibitor
Function / Pharmacology：Inhibitor of cyclic GMP-AMP synthase (cGAS), an important innate immune system sensor of foreign cytoplasmic double-stranded DNA.1,2 IC50 = 0.70 µM in dsDNA-stimulated RAW macrophages1 and ~0.80 µM in wild type human THP-1 cells2. It is selective for cGAS with no targeting of IFNB1 protein, interferon receptors, or downstream signaling components of the JAK/STAT pathway. RU.521 was able to significantly increase cardiac output in a mouse model of sepsis.3 Active in both mouse and human cell lines.
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文献和实验该产品被引用文献
2262452-06-0
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RU.521
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