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- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
SX-682
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
1648843-04-2
纯度：98% by HPLC；NMR (Conforms)
分子式：C19H14BF4N3O4S
分子量：467.20
溶剂：DMSO (>25 mg/ml)
性状：Off-white solid
存储：-20°C
Activity (short version)：CXCR1/2 inhibitor
Function / Pharmacology：SX-682 is a novel CXCR1/2 inhibitor (IC50s: CXCR1 = 42 nM, CXCR2 = 20 nM)1. It displayed robust synergistic activity with immune checkpoint blockade against castration resistant prostate cancer.2 It significantly reduced tumor burden in a Ptenfl/fl/Lkb1fl/fl mouse model of lung squamous cell cancer when used in combination with anti-PD1 therapy.3 SX-682 significantly inhibited trafficking of neutrophilic myeloid-derived suppressor cells (PMN-MDSCs) enhancing anti-PD1 immune checkpoint blockade, T cell-based immunotherapy, and NK-cell immunotherapy.4,5
分子式：C19H14BF4N3O4S
分子量：467.20
溶剂：DMSO (>25 mg/ml)
性状：Off-white solid
存储：-20°C
Activity (short version)：CXCR1/2 inhibitor
Function / Pharmacology：SX-682 is a novel CXCR1/2 inhibitor (IC50s: CXCR1 = 42 nM, CXCR2 = 20 nM)1. It displayed robust synergistic activity with immune checkpoint blockade against castration resistant prostate cancer.2 It significantly reduced tumor burden in a Ptenfl/fl/Lkb1fl/fl mouse model of lung squamous cell cancer when used in combination with anti-PD1 therapy.3 SX-682 significantly inhibited trafficking of neutrophilic myeloid-derived suppressor cells (PMN-MDSCs) enhancing anti-PD1 immune checkpoint blockade, T cell-based immunotherapy, and NK-cell immunotherapy.4,5
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文献和实验该产品被引用文献
1648843-04-2
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SX-682
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