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- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
Methylbenzoprim
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
118344-71-1
纯度：>98% by HPLC；NMR (Conforms)
分子式：C20H22N6O2
分子量：378.44
溶剂：DMSO (15 mg/ml)
性状：Red/Orange solid
存储：-20°C
Activity (short version)：Dual TYMS/DHFR inhibitor
Function / Pharmacology：Methylbenzoprim, a derivative of the antimalarial drug Pyrimethamine, is a non-classical potent inhibitor of mammalian dihydrofolate reductase (IC50 = 3.2 nM rat liver).1 It inhibited melanoma tumor growth both in vitro and in vivo.2 Methylbenzoprim has been recently found to also inhibit thymidylate synthase (TYMS) with activity comparable to the 5-FU metabolite FdUrd.3 It was more potent than 5-fluorouracil in a panel of 4 pancreatic ductal adenocarcinoma cells lines and without TYMS overexpression that frequently leads to drug resistance.3 Methylbenzoprim inhibited tumor growth and progression in two pancreatic cancer xenograft models. Orally bioavailable.
分子式：C20H22N6O2
分子量：378.44
溶剂：DMSO (15 mg/ml)
性状：Red/Orange solid
存储：-20°C
Activity (short version)：Dual TYMS/DHFR inhibitor
Function / Pharmacology：Methylbenzoprim, a derivative of the antimalarial drug Pyrimethamine, is a non-classical potent inhibitor of mammalian dihydrofolate reductase (IC50 = 3.2 nM rat liver).1 It inhibited melanoma tumor growth both in vitro and in vivo.2 Methylbenzoprim has been recently found to also inhibit thymidylate synthase (TYMS) with activity comparable to the 5-FU metabolite FdUrd.3 It was more potent than 5-fluorouracil in a panel of 4 pancreatic ductal adenocarcinoma cells lines and without TYMS overexpression that frequently leads to drug resistance.3 Methylbenzoprim inhibited tumor growth and progression in two pancreatic cancer xenograft models. Orally bioavailable.
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118344-71-1
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Methylbenzoprim
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