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- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
Verrucarin A
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
3148-09-2
纯度：>98% by HPLC,；NMR (Conforms)
分子式：C27H34O9
分子量：502.56
溶剂：DMSO (25 mg/ml)
性状：Off-white solid
存储：-20°C
Activity (short version)：Steroid receptor coactivator-3 inhibitor
Function / Pharmacology：A macrocyclic trichothecene mycotoxin from Myrothecium sp. It is a potent and selective inhibitor of the steroid receptor coactivator-3 and selectively down-regulates its expression.1 It is cytotoxic to multiple types of cancer cells at low nM concentrations (IC50=4.9 nM for HepG2 cells) but not toward normal liver cells.1,2 It enhances TNFα-induced3 and TRAIL-induced apoptosis4. It reduces phosphorylation of IREα and inhibits tunicamycin-induced ER stress in FaO rat liver cells.5
分子式：C27H34O9
分子量：502.56
溶剂：DMSO (25 mg/ml)
性状：Off-white solid
存储：-20°C
Activity (short version)：Steroid receptor coactivator-3 inhibitor
Function / Pharmacology：A macrocyclic trichothecene mycotoxin from Myrothecium sp. It is a potent and selective inhibitor of the steroid receptor coactivator-3 and selectively down-regulates its expression.1 It is cytotoxic to multiple types of cancer cells at low nM concentrations (IC50=4.9 nM for HepG2 cells) but not toward normal liver cells.1,2 It enhances TNFα-induced3 and TRAIL-induced apoptosis4. It reduces phosphorylation of IREα and inhibits tunicamycin-induced ER stress in FaO rat liver cells.5
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文献和实验该产品被引用文献
3148-09-2
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Verrucarin A
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