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- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
Hydroxyurea
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
127-07-1
分子式：CH4N2O2
分子量：76.06
溶剂：Water (50 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：Anticancer agent
Function / Pharmacology：Readily oxidized in vivo to free radical forms, which destroy the stable tyrosyl free radical of the metalloenzyme ribonucleotide reductase, suppressing deoxyribonucleotide production and blocking DNA synthesis and repair.1,2 Reduces cell proliferation, and causes S-phase arrest and death.3 Induces p53-dependent NF-κB target gene expression in U2OS cells expressing HA-RelA.4 Stimulates fetal hemoglobin production in vitro and in vivo.5 Allows for S phase enrichment of CHO cells with maintenance of viability for enhanced site-specific genome engineering.6 Anticancer and antiviral agent.
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文献和实验Determination of Hydroxyurea in Serum or Plasma Using Gas Chromatography-Mass Spectrometry (GC-MS)
Hydroxyurea is an antineoplastic drug, which is also widely used in the treatment of sickle cell disease. Various methods including colorimetry, high performance liquid chromatography, and gas chromatography-mass spectrometry (GC
Synchronization of Medicago sativa Cell Suspension Culture
culture that can be used for efficient synchronization of the cell division and also the application and removal of hydroxyurea blocking agent. A novel method is used for the estimation of cell portion that enters S phase during the assay. The protocol
Genetic Complementation Protocols
, this chapter discusses genetic complementation of an E. coli strain defective in expression of the small subunit of ribonucleotide reductase (NrdB). Wild-type NrdB, in trans , is used to complement the hydroxyurea hypersensitivity of the defective strain
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