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- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
Purvalanol A
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
212844-53-6
纯度：98% by HPLC,；NMR (Conforms)
分子式：C19H25ClN6O
分子量：388.89
溶剂：DMSO (35 mg/ml)
性状：Pale green solid
存储：-20°C
Activity (short version)：CDK inhibitor
Function / Pharmacology：Cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1 Reversibly arrests synchronized cells in G1 and G2 phase.2 Induces ER stress-mediated apoptosis and autophagy in colon cancer cells.3 Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.4 In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis.5 Cell permeable.
分子式：C19H25ClN6O
分子量：388.89
溶剂：DMSO (35 mg/ml)
性状：Pale green solid
存储：-20°C
Activity (short version)：CDK inhibitor
Function / Pharmacology：Cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1 Reversibly arrests synchronized cells in G1 and G2 phase.2 Induces ER stress-mediated apoptosis and autophagy in colon cancer cells.3 Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.4 In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis.5 Cell permeable.
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文献和实验该产品被引用文献
212844-53-6
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Purvalanol A
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