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- 文献和实验
- 技术资料
- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
Roflumilast
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
162401-32-3
纯度：98% by HPLC,；NMR (Conforms)
分子式：C17H14N2Cl2F2O3
分子量：403.21
溶剂：DMSO (25 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：PDE4 inhibitor
Function / Pharmacology：Potent and selective phosphodiesterase (PDE4) inhibitor, IC50=0.7, 0.9, 0.7, 0.2 nM for PDE4A1, PDE4A4, PDE4B1 and PDE4B2 respectively1. Clinically useful agent for treatment of COPD2. Improves sensory gating in humans3 and improves memory in rodent models4. Mimics calorie restriction effects via activation of AMPK/SIRT1 and protects against diabetic nephropathy5. Reduces weight gain by increasing energy expenditure and improves glucose metabolism in mice6.
分子式：C17H14N2Cl2F2O3
分子量：403.21
溶剂：DMSO (25 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：PDE4 inhibitor
Function / Pharmacology：Potent and selective phosphodiesterase (PDE4) inhibitor, IC50=0.7, 0.9, 0.7, 0.2 nM for PDE4A1, PDE4A4, PDE4B1 and PDE4B2 respectively1. Clinically useful agent for treatment of COPD2. Improves sensory gating in humans3 and improves memory in rodent models4. Mimics calorie restriction effects via activation of AMPK/SIRT1 and protects against diabetic nephropathy5. Reduces weight gain by increasing energy expenditure and improves glucose metabolism in mice6.
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文献和实验该产品被引用文献
162401-32-3
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Roflumilast
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