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- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
Reparixin
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
266359-83-5
纯度：99% by HPLC；NMR (Conforms)
分子式：C14H21NO3S
分子量：283.39
溶剂：DMSO (100 mg/ml) Ethanol (25 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：CXCR 1/2 allosteric antagonist
Function / Pharmacology：Reparixin is a noncompetitive allosteric inhibitor of IL-8 (CXCL8) activation of CXCR1 and CXCR2 chemokine receptors (IC50 = 1 and 100 nM, respectively). It blocks a number of activities related to IL-8 signaling, including leukocyte recruitment (IC50 = 1 nM) without affecting receptor activation induced by other CXCR1 and CXCR2 agonists.1 In spontaneously hypertensive rats, 5 mg/kg reparixin administered daily for three weeks was shown to reduce blood pressure by inhibiting hypertension-related mediators.2 It attenuates inflammatory responses and promotes recovery of function after traumatic lesion to the spinal cord.3 Reparixin blockade (100 nM) of CXCR1 has also been used to deplete a cancer stem cell population in human breast cancer cell lines in vitro.4
分子式：C14H21NO3S
分子量：283.39
溶剂：DMSO (100 mg/ml) Ethanol (25 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：CXCR 1/2 allosteric antagonist
Function / Pharmacology：Reparixin is a noncompetitive allosteric inhibitor of IL-8 (CXCL8) activation of CXCR1 and CXCR2 chemokine receptors (IC50 = 1 and 100 nM, respectively). It blocks a number of activities related to IL-8 signaling, including leukocyte recruitment (IC50 = 1 nM) without affecting receptor activation induced by other CXCR1 and CXCR2 agonists.1 In spontaneously hypertensive rats, 5 mg/kg reparixin administered daily for three weeks was shown to reduce blood pressure by inhibiting hypertension-related mediators.2 It attenuates inflammatory responses and promotes recovery of function after traumatic lesion to the spinal cord.3 Reparixin blockade (100 nM) of CXCR1 has also been used to deplete a cancer stem cell population in human breast cancer cell lines in vitro.4
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文献和实验该产品被引用文献
266359-83-5
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Reparixin
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