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- 保存条件：
-20°C
- 保质期：
咨询
- 英文名：
AMG 510
- 库存：
1000+
- 供应商：
上海维亦特生物
- CAS号：
2296729-00-3
纯度：>98% by HPLC ,；NMR (Conforms)
分子式：C30H30F2N6O3
分子量：560.61
溶剂：DMSO (>25 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：Covalent KRASG12C Inhibitor
Function / Pharmacology：AMG 510 is a potent (IC50’s = 6 nM NCI-H358; 9 nM MIA PaCa-2) covalent KRASG12C inhibitor.1,2 It significantly inhibited tumor growth in NCI-H358 and MIA PaCa-2 cell lines as well as CT-26 tumors (mouse syngeneic model) and caused tumor regression at higher doses.1 AMG 510 improved the efficacy of various other chemotherapeutic agents including inhibitors of HER kinases, EGFR, SHP2, PI3K, AKT, and MEK 1,3 and synergized with immune checkpoint reagents1. FDA approved for use in KRASG12C-positive non-small cell lung cancer. AMG 510 displayed efficacy alone4,5 and in combination5 with trametinib and/or buparlisib in pancreatic ductal adenocarcinoma cell lines.
分子式：C30H30F2N6O3
分子量：560.61
溶剂：DMSO (>25 mg/ml)
性状：White solid
存储：-20°C
Activity (short version)：Covalent KRASG12C Inhibitor
Function / Pharmacology：AMG 510 is a potent (IC50’s = 6 nM NCI-H358; 9 nM MIA PaCa-2) covalent KRASG12C inhibitor.1,2 It significantly inhibited tumor growth in NCI-H358 and MIA PaCa-2 cell lines as well as CT-26 tumors (mouse syngeneic model) and caused tumor regression at higher doses.1 AMG 510 improved the efficacy of various other chemotherapeutic agents including inhibitors of HER kinases, EGFR, SHP2, PI3K, AKT, and MEK 1,3 and synergized with immune checkpoint reagents1. FDA approved for use in KRASG12C-positive non-small cell lung cancer. AMG 510 displayed efficacy alone4,5 and in combination5 with trametinib and/or buparlisib in pancreatic ductal adenocarcinoma cell lines.
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文献和实验该产品被引用文献
2296729-00-3
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AMG 510
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